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IL-6在不同病程精神分裂症患者中的差异以及与认知的关系
刘莹李美娟高营仇玉莹赵永萍李洁
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目的 探索IL-6 在不同病程的精神分裂症患者中的差异,以及IL-6 水平与认知损害的相 关性。方法 研究采取横断面调查,将65 例单一服用奥氮平治疗的精神分裂症患者根据病程分为中长 病程组(1~10 年,33 例)和长病程组(> 10 年,32 例)。采集患者的基本信息,使用阳性与阴性症状量表 评定精神症状,使用连线测试、符号编码测试、霍普金斯词语学习测验、简易视觉空间记忆测验、持续操 作测验进行认知检测,采集患者血样检测血清IL-6 水平。结果 (1)中长病程组和长病程组血清IL-6 水 平分别为3.05(1.67, 4.26)pg/ml、1.62(1.52, 3.43)pg/ml,两组间差异有统计学意义(Z=-3.09,P < 0.05); (2)仅长病程组血清IL-6 水平与连线测试得分存在负相关性(r=-0.39,P < 0.05)。结论 不同病程的患 者IL-6 水平存在显著差异,在病程≥ 10 年的患者中IL-6 水平可能与执行功能存在负相关。
基金项目:
Difference of serum interleukin-6 level in schizophrenic patients with different illness duration and theirrelationship with cognition impairment
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Abstract:
Objectives To investigate the differences of serum interleukin-6( IL-6) level in schizophrenic patients with different illness duration, and the correlation between serum IL-6 level and cognitive impairment. Methods The cross-sectional study was conducted. A total of 65 schizophrenic patients treated with olanzapine monotherapy were enrolled in the study. All the patients were grouped into two groups: the medium course group( 1-10 years, n=33) and the long course group( >10 years,n=32). The basic information of patients was collected. Positive and Negative Symptoms Scale( PANSS) was applied to evaluate the psychiatric symptoms. Cognitive tests were carried out using Trail Making Test( TMT), Brief Assessment of Cognition in Schizophrenia( BACS), Hopkins Verbal Learning Test-revised( HVLT-R), Brief Visuospatial Memory Testrevised( BVMT-R) and Continuous Performance Test-identical pair test( CPT-IP). The serum IL-6 level of all patients were measured. Results (1) The level of IL-6 in the medium course group and the long course group was 3.05( 1.67, 4.26) pg/ml and 1.62( 1.52, 3.43) pg/ml respectively, and the difference was statistically significant( Z=-3.09, P< 0.05).( 2) There was a negative correlation between IL-6 and the TMT score in the long course group( r=-0.39,P< 0.05). Conclusions There are significant differences in IL-6 levels among patients with different course of disease. IL-6 levels may be negatively correlated with executive function in patients with course of disease more than 10 years.

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