方法 本研究为单中心、横断面研究，筛查2016 年2—12 月就诊于首都医科大学附属北京安定医院门
资料、疾病临床特征。结果 共纳入121 例受试者，其中有残留抑郁症状患者23.1%（28/121）。临床痊
愈与残留抑郁症状两组在性别（χ2=17.90，P＜ 0.01）、急性期伴有睡眠障碍（χ2=7.37，P=0.01）、近2 年的
Residual symptoms after treatment of acute depressive episodes in patients with bipolar disorder andtheir influencing factors
Objectives To explore the residual symptoms and its influencing factors after the treatment
of bipolar disorder in the acute phase of depression. Methods This is a single center， cross-sectional study.
Clinical data from the medical records of 130 outpatient or hospitalized patients with bipolar disorder（ BD） whose
last episode was depression and were treated in Beijing Anding Hospital between February and December 2016
was collected. A total of 121 cases were included in this study. Patients' demographic and clinical data were
collected using a mix of standardized scales and interviews. Results A total of 121 patients were interviewed
in this study. The proportion of patients with residual depressive symptoms was 23.1%（ 28/121）. Gender（ χ2 =17.90，
P ＜ 0.01）， acute phase with sleep disorders（ χ2 =7.37，P=0.01）， episode times in the past two years
（Z=-2.46，P=0.01） were significantly different between clinical remission group and residual symptom group.
Multiple logistic regression analysis demonstrated that male， acute phase with sleep disorders， more episode
times in the past two years were independently associated with residual depressive symptoms. Patients with
residual depressive symptoms were more depressive and significantly more impaired than the remission group.
Conclusions Residual depressive symptoms may occur in some patients after the acute phase of bipolar
depression. Being male， more episode times in the past two years were significantly associated with residual
depressive symptoms. Residual depressive symptoms have negatively impact on patients so we should strive to
enhance treatment plans to improve the prognosis.