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心境稳定剂治疗阿尔茨海默病行为和精神症状的 研究进展
翟倩丰雷张国富刘敏王晶晶
()
fszhuche.com:
阿尔茨海默病(AD)是一种进行性加重的神经退行性疾病,70%~90% 的AD 患者在疾病 的某一时期出现过痴呆的行为和精神症状(BPSD)。有研究显示心境稳定剂可以减缓神经元的丧失及神 经退行性变进程,从而减轻BPSD。心境稳定剂常用于BPSD 的临床治疗,并且具有较好的疗效。然而, 目前为止,有关心境稳定剂治疗BPSD 的研究结果缺乏一致性,同时属于超说明书用药,因此,其疗效及 安全性需要进一步科学的研究加以证实,并且促进药品说明书的进一步完善,让心境稳定剂治疗BPSD 有据可依。
基金项目:国家重点研发计划项目(2017YFC1311101)
Mood stabilizers in the treatment of behavioral and psychological symptoms of Alzheimer disease
Zhai Qian, Feng Lei, Zhang Guofu, Liu Min, Wang Jingjing
()
Abstract:
Alzheimer disease( AD) is a progressive neurodegenerative disease, 70%-90% of AD patients have behavioral and psychological symptoms of dementia( BPSD) at some point in the disease. Studies have shown that mood stabilizers can slow the loss of neurons and neurodegenerative processes and relieve BPSD. Mood stabilizers are often used in the treatment of BPSD and received good clinical effects. However, so far, the research outcomes on mood stabilizer in the treatment of BPSD are inconsistent. Using mood stabilizers to treat BPSD in AD is still off-label drug use. Therefore, the efficacy and safety of mood stabilizers in the treatment of BPSD of AD need to be determined by further scientific research, and the drug use instructions need to be updated as well, to make the treatment of BPSD with mood stabilizer well documented.

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