Research progress in the drug resistance mechanisms of anti-epileptic drugs in refractory epilepsytreatment
Zhang Yingju， Hou Liya， Feng Lirong， Zhu Ling， Ma Hongbing， Zhao Long， Li Yuanming，
For about 30% of epilepsy patients on antiepileptic drugs， the progression of epileptic
seizures are not completely under control. The treatment for epileptic seizures is difficult and the duration
of symptoms is relatively long. The brain lesions such as hippocampal sclerosis can be seen by imaging
examination. The drug resistance mechanism of refractory epilepsy is a key topic in current medical research.
By investigating the drug resistance mechanism， we can start to provide empirical basis for clinical treatment.
In this paper， both Chinese and international research progress of the drug resistance mechanism in refractory
epilepsy patients are reviewed and summarized， so as to further understand the disease and provide reference for
the future research on targeted treatment strategies.